Minisatellite MS32 Alleles Show Population Specificity Among Thai, Chinese, and Japanese
نویسندگان
چکیده
منابع مشابه
Human minisatellite MS32 (D1S8) displays somatic but not germline instability in transgenic mice.
Human minisatellite MS32 (D1S8) shows instability both in the germline and, at much lower levels, in somatic DNA. To investigate factors that influence somatic and germline mutation, large cosmid-based constructs containing MS32 were introduced into mice, bred to homozygosity and tested for instability in blood and sperm. Analysis of single copy and multicopy transgenic lines revealed somatic m...
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The human hypervariable minisatellite MS32 has a well characterised internal repeat unit array and high mutation rates have been observed at this locus. Analysis of MS32 mutants has shown that male germline mutations are polarised to one end of the array and frequently involve complex gene conversion-like events, suggesting that tandem repeat instability may be modulated by cis-acting sequences...
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متن کاملMinisatellite DNA Markers in Population Studies
The discovery of an anonymous multiallelic locus in 1980 demonstrated for the first time that the human DNA contains hypervariable regions (Wyman & White, 1980). Eight alleles of a polymorphic locus that was not associated with any known gene were identified during the blot hybridization of total human genomic DNA treated with the restrictase EcoRI with a human DNA fragment (16 tbp in length) i...
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ژورنال
عنوان ژورنال: Journal of Molecular Evolution
سال: 2009
ISSN: 0022-2844,1432-1432
DOI: 10.1007/s00239-008-9196-z